Water → 2,2,4,4-Tetramethylpentan-3-amine

HRID 330124노트

반응식

HRID 330124 반응식
[C:1]([C:5](=[NH:10])[C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:2][C:1]([CH3:4])([CH:5]([NH2:10])[C:6]([CH3:9])([CH3:8])[CH3:7])[CH3:3]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 27556322,2,4,4-Tetramethyl-3-pentanone ImineHCID 21226445Aluminium lithium hydride

생성물 1

HCID 131658882,2,4,4-Tetramethylpentan-3-amine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

The imine (14 g.) in dry ether (50 ml.) was added to a suspension of lithium aluminum hydride (1.7 g.) in dry ether (50 ml.). The mixture was stirred at room temperature for 24 hours, refluxed two hours and cooled. Water (1.7 ml.), 15% sodium hydroxide solution (5 ml.) and water (5 ml.) were added cautiously in succession, the mixture filtered, concentrated and the residue distilled to afford the desired amine, b.p. 79°-81° C./40 mm.

후처리

  1. temperaturerefluxed two hours
  2. temperaturecooled
  3. filtrationthe mixture filtered
  4. concentrationconcentrated
  5. distillationthe residue distilled

출처 및 근거

ORD 기록
ord-6595e9a24de6418a80a31736eed31999
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04894464

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