2-(3,4-Dimethylphenyl)acetonitrile → 2-(3,4-dimethylphenyl)-N'-hydroxyethanimidamide

HRID 330250

반응식

HRID 330250 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl.[NH2:13][OH:14].C[O-].[Na+].CO>CO>[OH:14][N:13]=[C:10]([NH2:11])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 764012-(3,4-Dimethylphenyl)acetonitrileHCID 443297Hydroxyamine hydrochlorideHCID 23694274Sodium methanolate methanol

생성물 1

HCID 51878672-(3,4-dimethylphenyl)-N'-hydroxyethanimidamide수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3,4-Dimethylphenylacetonitrile (10 g, 0.069 mol) was added to a mixture of hydroxylamine hydrochloride (9.57 g, 0.14 mol), methanol (100 mL) and 25% sodium methoxide/methanol (31.5 mL, 0.14 mol) at room temperature. After stirring for 16 hours at room temperature, the reaction mixture was concentrated in vacuo. The resultant oil was partitioned between methylene chloride and water. The organic phase was separated, washed with water, dried over magnesium sulfate and concentrated in vacuo to yield the desired product (11.4 g, 93%) as a white solid. Recrystallization from toluene afforded an analytical sample m.p. 59°-60° C.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customThe resultant oil was partitioned between methylene chloride and water
  3. customThe organic phase was separated
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2151eb6996b04815873593e7d1dea55c
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895862

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