Hydrochloric Acid → HCID 19869692, 화합물

HRID 330298노트

반응식

HRID 330298 반응식
[N:1]1[C:2]([C:13]([O:15]CC)=O)=[CH:3][N:4]2[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.[BH4-].[Li+].Cl.[C:21](=O)(O)[O-:22].[Na+]>CCO>[CH3:21][O:22][C:10]1[CH:11]=[CH:12][C:7]2[S:6][C:5]3=[N:1][C:2]([CH2:13][OH:15])=[CH:3][N:4]3[C:8]=2[CH:9]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 1480574ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylateHCID 4148881Lithium borohydride

생성물 1

HCID 19869692HCID 19869692, 화합물수율 96.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

A mixture of 4.0 g of ethyl imidazo[2,1-b]benzothiazole-2-carboxylate in dry T.H.F. was stirred with 1.5 g of lithium borohydride for 48 hours at room temperature under dry nitrogen. The mixture was treated with an excess of 2N hydrochloric acid and warmed to 50° C. for 2 hours to decompose the complex. The mixture was made alkaline with aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness under reduced pressure to obtain 3.27 g (96.4% yield) of 6-methoxy-imidazo[2,1-b]benzothiazole-2-methanol as a colorless solid melting at 189° to 190° C. (EtOH).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe extracts were dried over magnesium sulfate
  3. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-6fe6b48c08d14785a556bfed9cbc3b5a
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895863

반응 노트

불러오는 중…