Water → HCID 14699389, 화합물

HRID 330306노트

반응식

HRID 330306 반응식
[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Cl)[CH2:2][CH3:3].[C-:13]#[N:14].[Na+].O.CCOCC>CS(C)=O>[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][C:13]#[N:14])[CH2:2][CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 3283Diethyl EtherHCID 8929Sodium CyanideHCID 19869706HCID 19869706, 화합물

생성물 1

HCID 14699389HCID 14699389, 화합물수율 54.1%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
50 °C

실험 절차

A 2 liter flask was charged with 367 grams (1.90 moles, 1.0 ec.) of crude 2-propoxybenzyl chloride in 700 ml of DMSO. The reaction is cooled by a water bath and 102 grams of sodium cyanide (2.09 moles, 1.1 eq.) was added and allowed to warm to 50° C. After the exotherm was complete, the reaction was stirred at room temperature overnight then worked up with water, dilute acid and ether. Removal of the solvent was followed by distillation (120°-150° C. at 1 mm) and gave 180 grams (54% Yield) of a light yellow oil.

후처리

  1. temperatureThe reaction is cooled by a water bath
  2. customRemoval of the solvent
  3. distillationwas followed by distillation (120°-150° C. at 1 mm)

출처 및 근거

ORD 기록
ord-e3c61b1b45b74504a49f239cd66a41d8
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895865

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