1,2-Dimethoxyethane → Pyridine-2,3-dicarboxamide

HRID 330362노트

반응식

HRID 330362 반응식
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.ClC[C:11]([N:13](CCCCCCCC)CCCCCCCC)=[O:12].C(N(C(C)C)CC)(C)C.C(COC)[O:40]C>CCCCCCC>[N:4]1[CH:5]=[CH:6][CH:7]=[C:8]([C:11]([NH2:13])=[O:12])[C:3]=1[C:2]([NH2:1])=[O:40]

참가 물질

6

반응물 4

HCID 80711,2-DimethoxyethaneHCID 195092-PyridinemethanamineHCID 81531DiisopropylethylamineHCID 2224152-chloro-N,N-dioctylacetamide

생성물 1

HCID 578921Pyridine-2,3-dicarboxamide

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

Pyridine diamide 5 was prepared according to the general procedure described in Example 8 using 2-(aminomethyl)pyridine (0.019 mol), 2-chloro-N,N-dioctylacetamide (0.056 mol), diisopropylethylamine (0.056 mol) and dimethoxyethane (30 mL). The product was isolated from the heptane extraction of the acidic aqueous layer. The product was made basic by extraction with aqueous NaOH. The organic solution was concentrated, and the residue was distilled (150°-200° C., 0.10 mm).

후처리

  1. extractionThe product was made basic by extraction with aqueous NaOH
  2. concentrationThe organic solution was concentrated
  3. distillationthe residue was distilled (150°-200° C., 0.10 mm)

출처 및 근거

ORD 기록
ord-c9141a8133c64220abe46a7366cd7001
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04895951

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