Hydrochloric Acid → 7a-(3-Propyl-5-isoxazolyl)-hexahydro-1h-pyrrolizine hydrochloride salt

HRID 3304노트

반응식

HRID 3304 반응식
[CH2:1]([C:4]1[CH:8]=[C:7]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[O:6][N:5]=1)[CH2:2][CH3:3].[ClH:17]>CCOCC>[ClH:17].[CH2:1]([C:4]1[CH:8]=[C:7]([C:9]23[CH2:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][CH2:16]3)[O:6][N:5]=1)[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 189347247a-(3-propyl-5-isoxazolyl)-hexahydro-1H-pyrrolizine

생성물 1

HCID 189347587a-(3-Propyl-5-isoxazolyl)-hexahydro-1h-pyrrolizine hydrochloride salt

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

7a-(3-propyl-5-isoxazolyl)-hexahydro-1H-pyrrolizine (265 mg, 1.30 mmol, from step 14a) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the precipitate was triturated with Et2O and dried to afford the title compound as a free flowing white powder. mp 97°-98° C. MS (NH3 /CI): m/z 207 (M+H+); 1H NMR (D2O, 300 MHz) δ0.92 (t, J=7.5 Hz, 3H), 1.63-1.75 (m, 2H), 2.20-2.40 (m, 6H), 2.59-2.71 (m, 4H), 3.30-3.38 (m, 2H), 3.70-3.78,(m, 2H), 6.65 (s, 1H); MS (CI/NH3) m/z: 221 (M+H)+.Anal. Calcd for C13H20N2O.HCl: C, 59.38; H, 7.89; N, 11.54. Found: C, 59.44; H, 7.94; N, 11.48.

후처리

  1. customThe solvent was removed
  2. customthe precipitate was triturated with Et2O
  3. customdried

출처 및 근거

ORD 기록
ord-402839b675474c22a8bd5c354e9adae4
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733912

반응 노트

불러오는 중…