Sodium hydride → N-[4-(t-butyloxycarbonyl)aminomethylbenzoyl]-4-benzyloxy-L-phenylalanine cyclohexylamide

A mixture of the above compound (II) (1.70 g), palladium black (0.20 g), cyclohexene (6 ml), and ethanol (50 ml) was reacted under reflux of ethanol. After cooling, the solid was filtered off and the filtrate was concentrated to obtain N-(t-butyloxycarbonyl)-4-hydroxy-L-phenylalanine 4-pipecolylamide (III) (1.36 g). The compound (III) was dissolved, without purification, in N,N-dimethylformamide (20 ml). To this solution was added oily sodium hydride (60% content) (0.16 g), followed by stirring at room temperature for 30 minutes. To this solution was added a solution of 4-picolyl chloride (0.50 g) in N,N-dimethylformamide (5 ml) and the reaction was carried out at room temperature for 7 hours. Ice water was added to the reaction mixture and the resultant oily proudct was extracted with ethyl acetate. After a conventional post-treatment, N-(t-butyloxycarbonyl)-4-(4-picolyloxy)-L-phenylalanine 4-pipecolylamide (IV) (1.20 g) was obtained. From the compound (IV), N-(trans-4-aminomethylcyclohexylcarbonyl)-4-(4-picolyloxy)-L-phenylalanine-4-pipecolylamide (0.85 g) following the procedure of Example 6.

1. waitthe reaction was carried out at room temperature for 7 hours
2. extractionthe resultant oily proudct was extracted with ethyl acetate

ORD 기록

ord-728e9c92fc304127a600243bf1863c65

출처 데이터셋

uspto-grants-1990_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04895842