2-Propanethiol → 5-Isopropylthio-pyrrolidin-2-one
반응식
[OH:1][CH:2]1[NH:6][C:5](=O)[CH2:4][CH2:3]1.[CH3:8][CH:9]([SH:11])[CH3:10]>CCOCC>[CH:9]([S:11][CH:5]1[NH:6][C:2](=[O:1])[CH2:3][CH2:4]1)([CH3:10])[CH3:8]참가 물질
4
실험 절차
A mixture of 9 g of 5-hydroxy-pyrrolidin-2-one in 40 cm3 of 2-propanethiol and 5 g of Amberlite resin IR 120 H is maintained for 80 hours at ambient temperature. After diluting with ether, filtering, and concentrating under reduced pressure, 8.5 g of the expected product is obtained. m.p. 77°-79° C., crystallized from isopropyl ether. m.p. 85°-87° C. after re-crystallization.
후처리
- filtrationfiltering
- concentrationconcentrating under reduced pressure
출처 및 근거
- ORD 기록
- ord-305946d9a6094476881ff00344e5235f
- 출처 데이터셋
- uspto-grants-1990_01
- 특허 번호
- US04897414
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