Hydroxyamine hydrochloride → N'-Hydroxy-2-(8-bromonaphthalenyl)ethanimidamide

HRID 330511노트

반응식

HRID 330511 반응식
C[O-].[Na+].Cl.[NH2:5][OH:6].[Br:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[C:16]([CH2:18][C:19]#[N:20])=[CH:15][CH:14]=[CH:13]2>CO>[OH:6][N:5]=[C:19]([NH2:20])[CH2:18][C:16]1[C:17]2[C:12](=[CH:11][CH:10]=[CH:9][C:8]=2[Br:7])[CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 703577032-(8-Bromonaphthalen-1-yl)acetonitrile

생성물 1

HCID 54554816N'-Hydroxy-2-(8-bromonaphthalenyl)ethanimidamide수율 62.2%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A mixture of NaOMe (25 wt % in MeOH, 1.6 ml, 6.83 mmol), MeOH (3 mL), and hydroxylamine hydrochloride (0.47 g, 6.83 mmol) was heated for 30 minutes. 8-Bromo-2-naphthalenylacetonitrile (1.12 g, 4.55 mmol) and MeOH (5 mL) were added and heating was continued for 24 hours. The mixture was concentrated, and suspended in H2O (40 mL) and ether (2 mL). The off-white solid was collected by filtration and triturated with ether to give the title compound (790 mg, 62%), m.p. 123°-125° C.

후처리

  1. temperaturewas heated for 30 minutes
  2. temperatureheating
  3. concentrationThe mixture was concentrated
  4. filtrationThe off-white solid was collected by filtration
  5. customtriturated with ether

출처 및 근거

ORD 기록
ord-e24a25eaa52f48dfa8a5731afc8f16f9
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04897405

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