Dimethyl Sulfoxide → 1-Naphthaleneacetonitrile, 3-methyl-

HRID 330522노트

반응식

HRID 330522 반응식
[C-:1]#[N:2].[K+].BrC[C:6]1[C:15]([CH3:16])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1.[CH3:17]S(C)=O>O>[CH3:16][C:15]1[CH:6]=[C:7]([CH2:17][C:1]#[N:2])[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 9032Potassium CyanideHCID 27530932-(Bromomethyl)-3-methylnaphthalene

생성물 1

HCID 703577721-Naphthaleneacetonitrile, 3-methyl-수율 81%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

KCN (1.81 g, 27.85 mmol) was added to a solution of 2-bromomethyl-3-methylnaphthalene (5.95 g, 25.32 mmol) in 150 mL of DMSO at room temperature. The resulting mixture was stirred 1 hour, diluted with water (175 mL) and stirred another 15 minutes. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to give the desired product (3.71 g g, 81%) of sufficient purity for use in the subsequent reaction.

후처리

  1. stirringstirred another 15 minutes
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-bf3cda173b29432bae3c27bf397bbc7f
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04897405

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