4-[3-(3-Methylphenyl)propyl]aniline → HCID 178461175, 화합물

HRID 330575

반응식

HRID 330575 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][C:11]2[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=2)[CH:5]=[CH:6][CH:7]=1>O1CCOCC1.[Ru](=O)=O>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@H:4]([CH2:8][CH2:9][CH2:10][C@@H:11]2[CH2:12][CH2:13][C@H:14]([NH2:15])[CH2:16][CH2:17]2)[CH2:3]1

참가 물질

4

반응물 1

HCID 141279284-[3-(3-Methylphenyl)propyl]aniline

생성물 1

HCID 178461175HCID 178461175, 화합물

시약·촉매·용매 2

HCID 82848Ruthenium dioxide촉매HCID 312751,4-Dioxane용매

반응 조건

온도
140 °C

실험 절차

0.5 g of ruthenium dioxide is added to a solution of 63 g (0.28 mole) of 4-[3-(3-methylphenyl)-propyl]aniline in 100 ml of dioxane, and hydrogenation is carried out in a 300 ml stirred autoclave at 140° C. and under an H2 pressure of 300 bar until the pressure remains constant (about 3 hours). The discharged mixture is filtered under suction over kieselguhr, the filtrate is evaporated down under reduced pressure and the residue is subjected to fractional distilation to give 47 g (71% of theory) of a colorless oil of boiling point 100°-116° C./0.2 mm, consisting of about 30% of the cis isomer and 70% of the trans isomer (compound no. 64).

후처리

  1. custom(about 3 hours)
  2. filtrationThe discharged mixture is filtered under suction over kieselguhr
  3. customthe filtrate is evaporated down under reduced pressure
  4. customthe residue is subjected to fractional distilation
  5. customto give 47 g (71% of theory) of a colorless oil of boiling point 100°-116° C./0.2 mm

출처 및 근거

ORD 기록
ord-dd6cad5c9c81435e8809df3bb5639a1c
출처 데이터셋
uspto-grants-1990_01
특허 번호
US04897425

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