반응식
CC(C)(O)[C:3]#[N:4].[NH3:7].Cl[CH2:9][CH2:10][CH2:11][C:12](=O)[CH2:13][CH2:14][CH2:15]Cl.[OH-].[Na+]>>[C:3]([C:12]12[CH2:13][CH2:14][CH2:15][N:7]1[CH2:9][CH2:10][CH2:11]2)#[N:4]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
To a solution of aceton cyanohydrin (2.3 g, 27 mmol) saturated with ammonia, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 48 hours at 20° C. under ammonia gas atmosphere. To the reaction mixture, 0.1N-NaOH was added to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.33 g of the desired compound (Yield: 89%).
후처리
- extractionto extract with methylene chloride
- dry with materialThe extract was dried over anhydrous sodium sulfate
- concentrationconcentrated
- distillationdistilled in vacuo
출처 및 근거
- ORD 기록
- ord-a85465a5215648fdaf2a095d239f17e5
- 출처 데이터셋
- uspto-grants-1990_01
- 특허 번호
- US04897495
연결된 노트
불러오는 중…