Acetic Anhydride → N-((1S)-1-(4-Bromophenyl)ethyl)acetamide

HRID 330761

반응식

HRID 330761 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 852999(alphaS)-4-Bromo-alpha-methylbenzenemethanamine

생성물 1

HCID 793484N-((1S)-1-(4-Bromophenyl)ethyl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

후처리

  1. customThen the cooling is removed
  2. washAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
  3. dry with materiallayer is dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-10572e9e42914c269065c8e47baaf881
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877741B2

연결된 노트

불러오는 중…