Diisopropylethylamine → HCID 86727989, 화합물

HRID 330764노트

반응식

HRID 330764 반응식
[Br:1][C:2]1(F)[CH:7]=[CH:6][CH:5]=[CH:4][NH:3]1.Cl.[F:10][CH:11]([F:15])[CH2:12][NH:13][CH3:14].CCN(C(C)C)C(C)C>>[Br:1][C:2]1[N:3]=[C:4]([N:13]([CH2:12][CH:11]([F:15])[F:10])[CH3:14])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 457923922,2-Difluoro-N-methylethan-1-amine--hydrogen chloride (1/1)HCID 67998121HCID 67998121, 화합물

생성물 1

HCID 86727989HCID 86727989, 화합물

실험 절차

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

후처리

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted with DCM
  3. dry with materiallayers are dried over MgSO4
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-fa724f70c7c0437fb9c2c24912c397c4
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877741B2

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