Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide

HRID 330782

반응식

HRID 330782 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][C:10]=1[OH:16]>C(O)(=O)C>[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[CH:11][C:10]=1[OH:16]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 806765-Amino-2-chlorophenol

생성물 1

HCID 14122483N-(4-Chloro-3-hydroxyphenyl)acetamide수율 93%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

후처리

  1. temperaturethe reaction was refluxed for 5 mins
  2. filtrationIt was filtered off
  3. washwashed with water (10 mL)
  4. customdried

출처 및 근거

ORD 기록
ord-b36c980b138d4933833e7cd7a8fdd153
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877752B2

연결된 노트

불러오는 중…