Water → HCID 66695588, 화합물

HRID 330817

반응식

HRID 330817 반응식
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].O>C1COCC1>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 104392-AminopyridineHCID 966574-IodobenzaldehydeHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 66695588HCID 66695588, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

2.00 g (8.62 mmol) 4-iodo-benzaldehyde are added to 0.811 g (8.62 mmol) 2-amino-pyridine in 20 mL THF and the mixture is stirred for 1 h at 50° C. After that time, 4.57 g (21.5 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 1 h at 50° C. Subsequently, water is added and the mixture is extracted with EtOAc. The organic layer is dried over magnesium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC to yield the desired product.

후처리

  1. stirringthe mixture is stirred for 1 h at 50° C
  2. extractionthe mixture is extracted with EtOAc
  3. dry with materialThe organic layer is dried over magnesium sulphate
  4. customthe solvent is removed in vacuo
  5. customThe residue is purified by RP-HPLC

출처 및 근거

ORD 기록
ord-ecc78df6dcc44bd7944d672c422118ab
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877754B2

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