참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | 4-Iodobenzaldehyde | HCID 96657 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 66695588 | HCID 66695588 | — |
반응 단계
2.00 g (8.62 mmol) 4-iodo-benzaldehyde are added to 0.811 g (8.62 mmol) 2-amino-pyridine in 20 mL THF and the mixture is stirred for 1 h at 50° C. After that time, 4.57 g (21.5 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 1 h at 50° C. Subsequently, water is added and the mixture is extracted with EtOAc. The organic layer is dried over magnesium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08877754B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-ecc78df6dcc44bd7944d672c422118ab |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
