反应详情

温度

50 °C

2.00 g (8.62 mmol) 4-iodo-benzaldehyde are added to 0.811 g (8.62 mmol) 2-amino-pyridine in 20 mL THF and the mixture is stirred for 1 h at 50° C. After that time, 4.57 g (21.5 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 1 h at 50° C. Subsequently, water is added and the mixture is extracted with EtOAc. The organic layer is dried over magnesium sulphate and the solvent is removed in vacuo. The residue is purified by RP-HPLC to yield the desired product.

1. stirringthe mixture is stirred for 1 h at 50° C
2. extractionthe mixture is extracted with EtOAc
3. dry with materialThe organic layer is dried over magnesium sulphate
4. customthe solvent is removed in vacuo
5. customThe residue is purified by RP-HPLC