N-Iodosuccinimide → 4-chloro-3-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C1C(=O)N([I:19])C(=O)C1>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[NH:9][CH:10]=[C:11]([I:19])[C:3]=12참가 물질
4
실험 절차
To a stirred solution of 4-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine (4.06 g, 24.37 mmol) in DCM (80 mL) at 0° C., was added NIS (6.22 g, 27.6 mmol). The reaction mixture was then warmed to RT and stirred for 18 hours. The reaction mixture was then filtered (washed with excess DCM) to give the title compound (4.01 g). LCMS (A): m/z (M+H)+ 293, C8H6ClIN2 requires 292 (acidic).
후처리
- filtrationThe reaction mixture was then filtered
- wash(washed with excess DCM)
출처 및 근거
- ORD 기록
- ord-d8ccce7840bd454ba996e1985f2eb47a
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877742B2
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