Sodium Hydroxide → 1,2,3,4-Tetrahydro-1-naphthaleneacetic acid

HRID 331223노트

반응식

HRID 331223 반응식
[CH:1]1([CH2:11][C:12]([O:14]CC)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:11][C:12]([OH:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12322859Ethyl 2-(1,2,3,4-tetrahydronaphthalen-1-yl)acetate

생성물 1

HCID 128585751,2,3,4-Tetrahydro-1-naphthaleneacetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl (1,2,3,4-tetrahydronaphthalen-1-yl)acetate (31.0 g) in ethanol (100 ml) was added sodium hydroxide (4N, 100 ml), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated to a half volume under reduced pressure, and the residue was washed with ethyl acetate. The aqueous layer was acidified with dilute hydrochloric acid, and extracted with chloroform. The obtained organic layer was washed with water and saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure to give (1,2,3,4-tetrahydronaphthalen-1-yl)acetic acid.

후처리

  1. concentrationThe reaction mixture was concentrated to a half volume under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. extractionextracted with chloroform
  4. washThe obtained organic layer was washed with water and saturated brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7b4169e97d424a269bd33292661e084e
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877779B2

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