Ethanol → 4-(2-Fluorophenyl)butanoic acid

HRID 331240

반응식

HRID 331240 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10](C(OC)=O)[C:11]([O:13]C)=[O:12].[OH-].[Na+].C(O)C>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 68704652Dimethyl 2-[2-(2-fluorophenyl)ethyl]malonate

생성물 1

HCID 154910364-(2-Fluorophenyl)butanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Dimethyl 2-[2-(2-fluorophenyl)ethyl]malonate, sodium hydroxide (22.7 g), ethanol (150 ml) and water (100 ml) were heated under reflux for 1.5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was acidified with hydrochloric acid, and extracted with chloroform. The extract was washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give 4-(2-fluorophenyl)butanoic acid.

후처리

  1. temperatureunder reflux for 1.5 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. extractionextracted with chloroform
  4. washThe extract was washed with water and saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c468c92760b24edfb6d15c08c6986f80
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877779B2

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