Hydrochloric Acid → 6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

HRID 331266노트

반응식

HRID 331266 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:3][CH2:2]1.[ClH:32].C(OCC)C>C(Cl)Cl>[ClH:32].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 509405096-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one

생성물 1

HCID 703126206-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one (500 mg, 1.21 mmol) obtained in Step 7 was placed into a flask and dissolved in CH2Cl2 (4.0 mL). To the resulting solution was added 1.0M HCl in diethyl ether (1.21 mL, 1 eq). The solvents were removed by rotary evaporation under reduced pressure to give the desired product in quantitative yield.

후처리

  1. customThe solvents were removed by rotary evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-36348c8524db40d7ba1d0b22bfb36247
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877747B2

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