Phenethyl bromide → HCID 51001890, 화합물

HRID 331311

반응식

HRID 331311 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>CC#N.CCOC(C)=O>[F:8][C:6]1[CH:5]=[C:4]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([O:18][CH2:33][CH2:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

6

반응물 3

HCID 7666Phenethyl bromideHCID 11430Potassium CarbonateHCID 703174323-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one

생성물 1

HCID 51001890HCID 51001890, 화합물수율 30%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one (0.15 mol, 50 mg) obtained in Step 1 in CH3CN was added K2CO3(1.5 eq). 1-(2-bromoethyl)benzene (1.5 eq) was added dropwise and the resulting mixture was heated to reflux for 3 d. The reaction was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H2O, dried over MgSO4, and concentrated in vacuo to obtain the title compound (30%).

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux for 3 d
  3. washThe organic layer was washed with H2O
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-86b7d8860c7e4b418708a2ff8c0b2c8a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877747B2

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