Hydrochloric Acid → HCID 67972354, 화합물

HRID 331402노트

반응식

HRID 331402 반응식
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:19]3[CH:20]=[CH:21][O:22][C:18]=3[C:17]([F:23])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[F:23][C:17]1[C:18]2[O:22][CH:21]=[CH:20][C:19]=2[C:14]([C:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=2)=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67972151HCID 67972151, 화합물

생성물 1

HCID 67972354HCID 67972354, 화합물수율 90.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 4-(7-fluoro-benzofuran-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.97 g, 3.06 mmol) in dichloromethane (23 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 11.5 ml, 45.8 mmol) and the reaction mixture was allowed to stir for 1.5 h. The reaction mixture was evaporated, the residue triturated with diethyl ether (50 ml) and MeOH (1 ml), the precipitate was collected by filtration, washed with diethyl ether and dried to yield 4-(7-fluoro-benzofuran-4-yl)-1,2,3,6-tetrahydro-pyridine hydrochloride as light yellow solid (0.7 g, 90%), MS (ISP) m/z=218.2 [(M+H)+], mp 202° C.

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue triturated with diethyl ether (50 ml) and MeOH (1 ml)
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with diethyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-7a85168600c54b748b4af98cbd512ab5
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877778B2

반응 노트

불러오는 중…