Dichloromethane → Tert-butyl (4-[4-[5-[bis(tert-butoxycarbonyl)amino]-6-ethynyl-pyrazin-2-yl]-2-pyridyl]-4-cyano-piperidine-1-carboxylate)

반응식

[C:1]([C:3]1([C:16]2[CH:21]=[C:20](I)[CH:19]=[CH:18][N:17]=2)[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1)#[N:2].B1(B2OC(C)(C)C(C)(C)O2)OC(C)(C)C(C)(C)O1.C([O-])(=O)C.[K+].ClCCl.Br[C:50]1[N:51]=[C:52]([C:71]#[C:72][Si](C)(C)C)[C:53]([N:56]([C:64]([O:66][C:67]([CH3:70])([CH3:69])[CH3:68])=[O:65])[C:57](=[O:63])[O:58][C:59]([CH3:62])([CH3:61])[CH3:60])=[N:54][CH:55]=1.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:12]([O:11][C:9]([N:6]1[CH2:7][CH2:8][C:3]([C:16]2[CH:21]=[C:20]([C:50]3[CH:55]=[N:54][C:53]([N:56]([C:64]([O:66][C:67]([CH3:70])([CH3:69])[CH3:68])=[O:65])[C:57]([O:58][C:59]([CH3:60])([CH3:61])[CH3:62])=[O:63])=[C:52]([C:71]#[CH:72])[N:51]=3)[CH:19]=[CH:18][N:17]=2)([C:1]#[N:2])[CH2:4][CH2:5]1)=[O:10])([CH3:15])([CH3:14])[CH3:13]