Potassium Carbonate → tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate

HRID 33165

반응식

HRID 33165 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 119282-ChloroquinolineHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 16117834tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 6.1 mmol 2-chloroquinoline, 6.7 mmol piperazine-1-carboxylic acid tert-butyl ester and 12.2 mmol potassium carbonate in 15 ml acetonitrile was refluxed overnight. The reaction mixture is concentrated, water is added and the compound extracted with ethyl acetate. Chromatography (SiO2; cyclohexane/ethyl acetate 9/1) gave the title compound as a colorless solid.

후처리

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture is concentrated
  3. additionwater is added
  4. extractionthe compound extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-a686448e25f6428e9d95799ac3023fb6
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429585B2

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