Methanol → HCID 67204923, 화합물

HRID 332074

반응식

HRID 332074 반응식
[CH:1]1[CH:6]=[C:5]2/[C:7](/C(N[C:4]2=[CH:3][CH:2]=1)=O)=C/C1NC=CC=1.[CH3:17][C:18]([O:23]/N=C(/C(NCC=O)=O)\C1N=C(N)SC=1)([C:20]([OH:22])=O)[CH3:19].N1CC[CH2:41][CH2:40][CH2:39]1.[CH3:44][OH:45]>>[CH2:7]([O:45][CH2:44][CH2:19][C@@:18]1([CH3:17])[CH2:20][O:22][C:40]([CH3:41])([CH3:39])[O:23]1)[C:5]1[CH:6]=[CH:1][CH:2]=[CH:3][CH:4]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 8082PiperidineHCID 5908088(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-oneHCID 15956689HCID 15956689, 화합물

생성물 1

HCID 67204923HCID 67204923, 화합물수율 81%

실험 절차

To a stirred solution of oxindole 1 (4.19 g, 25 mmol) in methanol (50 mL) was added aldehyde 2 (3.96 g, 25 mmol) and piperidine (2.45 mL, 25 mmol). The reaction mixture was stirred at room temperature for 3 h and the yellow precipitate was collected, washed successively with methanol, hexanes, and ethyl ether and dried to give compound 3 (6.25 g, 81% yield).

후처리

  1. customthe yellow precipitate was collected
  2. washwashed successively with methanol, hexanes, and ethyl ether
  3. customdried

출처 및 근거

ORD 기록
ord-f7e546787b0b48b78a554e039112702f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877796B2

연결된 노트

불러오는 중…