Hydrochloric Acid → Ethyl 2-formyl-1,3-thiazole-4-carboxylate

HRID 332600노트

반응식

HRID 332600 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11](OCC)[O:12]CC)[S:9][CH:10]=1)=[O:5])[CH3:2].Cl>CC(C)=O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11]=[O:12])[S:9][CH:10]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 16220290Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate

생성물 1

HCID 11355896Ethyl 2-formyl-1,3-thiazole-4-carboxylate

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

2-(Diethoxymethyl)-4-thiazolecarboxylic acid ethyl ester (2.90 g, 11.8 mmol) synthesized according to Bull. Chem. Soc. Jpn., 58, 352 (1985), which is incorporated herein by reference in its entirety, was dissolved in acetone (37.3 mL), 1N aqueous hydrochloric acid solution (3.73 mL) was added, and the mixture was stirred with heating at 60° C. for 4 hours. After evaporation of the solvent, the mixture was worked up according to a conventional method to give the title compound as a crude product (2.13 g).

후처리

  1. customAfter evaporation of the solvent

출처 및 근거

ORD 기록
ord-fea23a868aa54df98316d3bff6ba4afb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877805B2

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