Hydrazinium chloride → HCID 178469379, 화합물

HRID 33269노트

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HRID 33269 반응식
[Na].[C:2]([O:12][CH2:13][CH3:14])(=[O:11])[CH2:3][C:4]([C:6](OCC)=[O:7])=O.Cl.[NH2:16][NH2:17]>C(O)C.O.Cl>[CH2:13]([O:12][C:2]([C:3]1[NH:16][N:17]=[C:6]([OH:7])[CH:4]=1)=[O:11])[CH3:14]

참가 물질

6

반응물 2

HCID 115031Hydrazinium chlorideHCID 57351814Diethyl 2-oxosuccinate,sodium salt

생성물 1

HCID 178469379HCID 178469379, 화합물

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To a solution of 5 g Diethyl Oxalacetate sodium salt in 100 ml ethanol, 1.5 g hydrazine monohydrochloride were added and the reaction mixture was heated to 80° C. for 3 h. Then the solution was diluted with 100 ml of water containing 3 ml of halfconcentrated HCl and extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was subjected to the next reaction step without further purification; Yield: 3.4 g

후처리

  1. extractionextracted with DCM (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude product was subjected to the next reaction step without further purification

출처 및 근거

ORD 기록
ord-1eaec0aabaf74bf68499db6ce002e679
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429581B2

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