Hydrochloric Acid → HCID 18934769, 화합물

HRID 3328

반응식

HRID 3328 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8].Cl>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 189347597a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

생성물 1

HCID 18934769HCID 18934769, 화합물수율 74%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (35 mg, 74%): mp 181°-183° C.; 1H NMR (D2O, 300 MHz) δ2.15-2.50 (m, 6H), 2.56-2.65 2H), 3.34-3.42 (m, 2H), 3.79-3.87 (m, 2H), 8.24-8.29 (m, 2H); MS (CI/NH3) m/z: 241 (M+H)+ ; MS (CI/NH3): m/z 241/243 (M+H+). Anal. Calcd for C12H14 ClFN2.HCl: C, 52.00; H, 5.45; N, 10.11. Found: C, 51.81; H, 5.62; N, 9.84.

후처리

  1. customThe solvent was removed
  2. customthe solid was triturated with Et2O
  3. customdried

출처 및 근거

ORD 기록
ord-de9abf64e74b42648268c346ed5db6f3
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733912

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