Ethylenediamine → N-(5-Ethyl-6-methyl-pyrimidin-4-yl)ethane-1,2-diamine hydrochloride

반응식

[Cl:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6]([CH3:10])[N:5]=[CH:4][N:3]=1.[NH2:11][CH2:12][CH2:13][NH2:14]>>[ClH:1].[CH2:8]([C:7]1[C:2]([NH:11][CH2:12][CH2:13][NH2:14])=[N:3][CH:4]=[N:5][C:6]=1[CH3:10])[CH3:9]

참가 물질

반응물 2

HCID 3301Ethylenediamine

HCID 612520254-Chloro-5-ethyl-6-methylpyrimidine

생성물 1

HCID 66834918N-(5-Ethyl-6-methyl-pyrimidin-4-yl)ethane-1,2-diamine hydrochloride수율 144.8%

반응 조건

온도: 150 °C

실험 절차

4-Chloro-5-ethyl-6-methylpyrimidin (570 mg, 4 mmol) was mixed with 1,2-diaminoethane (2 ml, 30 mmol) and stirred at 150° C. in a closed vessel under microwave heating. The mixture was evaporated to dryness under reduced pressure to yield 1.255 g of a solid. MS (APCI) m/z=181.1 [M+H]+.

후처리

temperatureheating
customThe mixture was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록: ord-a2eefbeaf0184e2bbe6b4eb241b7ac72
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08877934B2

반응 노트

불러오는 중…