Hydrochloric Acid → N2-(2,6-Dimethyl-4-pyridyl)propane-1,2-diamine hydrochloride
반응식
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][CH:9]([CH3:19])[CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[C:4]([CH3:20])[N:3]=1.[ClH:21]>O1CCOCC1>[ClH:21].[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][CH:9]([CH3:19])[CH2:10][NH2:11])[CH:5]=[C:4]([CH3:20])[N:3]=1참가 물질
4
실험 절차
To tert-butyl 2-(2,6-dimethylpyridin-4-ylamino)propylcarbamate (147 mg, 0.526 mmol) dissolved in 1,4-dioxane (1 ml) a 4N solution of HCl in dioxane (2 ml, 8.00 mmol) was added. Within a few minutes a precipitate started to form. The solvent was removed in a stream of nitrogen, to the residue was added diethylether and the mixture was allowed to stand at room temperature overnight. The solvent was filtered off, the residue was dried under reduced pressure to yield 135 mg of an off-white solid MS (ESI) m/z=180.0.
후처리
- additionwas added
- waitWithin a few minutes a precipitate started
- customto form
- customThe solvent was removed in a stream of nitrogen, to the residue
- additionwas added diethylether
- filtrationThe solvent was filtered off
- customthe residue was dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-23b3de78bbb24b248281e8b8438fb5c3
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877934B2
반응 노트
불러오는 중…