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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Lithium Hydroxide → (S)-5-((S)-4-carboxy-1-(4-iodobenzylamino)-1-oxobutan-2-ylamino)-5-oxo-4-(3-(4-sulfamoylphenyl)thioureido)pentanoic Acid

HRID 333134
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인쇄 미리보기

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HRID 333134 반응식
[I:1][C:2]1[CH:42]=[CH:41][C:5]([CH2:6][NH:7][C:8](=[O:40])[C@@H:9]([NH:16][C:17](=[O:39])[C@@H:18]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][C:32]([S:35](=[O:38])(=[O:37])[NH2:36])=[CH:31][CH:30]=2)=[S:27])[CH2:19][CH2:20][C:21]([O:23]C)=[O:22])[CH2:10][CH2:11][C:12]([O:14]C)=[O:13])=[CH:4][CH:3]=1.[OH-].[Li+]>CO.O>[C:12]([CH2:11][CH2:10][C@H:9]([NH:16][C:17](=[O:39])[C@@H:18]([NH:25][C:26]([NH:28][C:29]1[CH:30]=[CH:31][C:32]([S:35](=[O:37])(=[O:38])[NH2:36])=[CH:33][CH:34]=1)=[S:27])[CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:8]([NH:7][CH2:6][C:5]1[CH:4]=[CH:3][C:2]([I:1])=[CH:42][CH:41]=1)=[O:40])([OH:14])=[O:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 86632285(S)-methyl 5-(4-iodobenzylamino)-4-((S)-5-methoxy-5-oxo-2-(3-(4-sulfamoylphenyl)thioureido)pentanamido)-5-oxopentanoate

생성물 1

HCID 86632286(S)-5-((S)-4-carboxy-1-(4-iodobenzylamino)-1-oxobutan-2-ylamino)-5-oxo-4-(3-(4-sulfamoylphenyl)thioureido)pentanoic Acid수율 25.9%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962
Water
용매

실험 절차

A solution of (S)-methyl 5-(4-iodobenzylamino)-4-((S)-5-methoxy-5-oxo-2-(3-(4-sulfamoylphenyl)thioureido)pentanamido)-5-oxopentanoate (0.200 g, 0.27 mmol) and lithium hydroxide (48 mg) in methanol (3.0 mL) and water (1.0 mL) was stirred at room temperature for overnight. The reaction mixture was purified by HPLC to give the title product (49.4 mg) as a yellow solid. MS (ESI), 728 (M+Na)+.

후처리

  1. customThe reaction mixture was purified by HPLC

출처 및 근거

ORD 기록
ord-32e53b8a481d474b9074c2cce1521d5c
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08877970B2

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