Water → HCID 66987908, 화합물

HRID 333416노트

반응식

HRID 333416 반응식
[NH2:1][C@@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:3]([O:5][CH3:6])=[O:4].O.Cl[C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=1)=[O:19].C(N(C(C)C)CC)(C)C>ClCCl>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][C@H:2]([NH:1][C:18]([O:20][C:21]2[CH:22]=[CH:23][C:24]([N+:27]([O-:29])=[O:28])=[CH:25][CH:26]=2)=[O:19])[C:3]([O:5][CH3:6])=[O:4])=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 10856719O-Methyl-L-tyrosine methyl ester

생성물 1

HCID 66987908HCID 66987908, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1 g (4.8 mmol) of methyl(S)-2-amino-3-(4-methoxyphenyl)propionate (cf. preparation 2-1) is diluted in 30 mL of dichloromethane. The solution is cooled in a bath of cold water, and 1.4 g (7.2 mmol) of 4-nitrophenyl chloroformate and 1.2 mL (7.2 mmol) of diisopropylethylamine are then added. After warming to room temperature, the reaction medium is stirred for 2 hours. The solution is poured into water and then extracted with dichloromethane. The organic phase is dried and then evaporated. The crude product obtained is used in the following step without further purification.

후처리

  1. additionare then added
  2. extractionextracted with dichloromethane
  3. customThe organic phase is dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-9f75dd7f3bcd41df80f6a154aeb2408b
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877968B2

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