Lithium Hydroxide → HCID 178463865, 화합물

HRID 333418노트

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HRID 333418 반응식
[CH2:1]([N:3]([CH2:21][CH2:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1)[C:4](=[O:20])[NH:5][C@@H:6]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:7]([O:9]C)=[O:8])[CH3:2].[OH-].[Li+]>C1COCC1.O>[CH2:1]([N:3]([CH2:21][CH2:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1)[C:4](=[O:20])[NH:5][CH:6]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)[C:7]([OH:9])=[O:8])[CH3:2]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 178463866HCID 178463866, 화합물

생성물 1

HCID 178463865HCID 178463865, 화합물수율 69.4%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

150 mg (0.4 mmol) of methyl(S)-2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propionate are diluted in 4 mL of THF and 1 mL of water, and 150 mg (6 mmol) of lithium hydroxide are added. The mixture is heated for 10 minutes at 100° C. in a microwave reactor. The solvents are evaporated off and the residue is then purified on a pad of silica (eluent: 1/1 dichloromethane/methanol). 100 mg of 2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propionic acid in the form of a pale yellow powder are obtained in a yield of 69%.

후처리

  1. customThe solvents are evaporated off
  2. customthe residue is then purified on a pad of silica (eluent: 1/1 dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-693d2af3870b46c687b562cc960d4560
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877968B2

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