Iodoethane → Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

HRID 333427노트

반응식

HRID 333427 반응식
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH:19]([N-]C(C)C)(C)[CH3:20].[Li+].ICC.[Cl-].[NH4+]>C1COCC1>[CH2:19]([C:6]1([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13])[CH2:8][CH2:7]1)[CH3:20]

참가 물질

6

반응물 4

HCID 6340IodoethaneHCID 25517Ammonium ChlorideHCID 2724682Lithium diisopropylamideHCID 27588121-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

생성물 1

HCID 53393415Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate수율 82.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.2 g (0.78 mmol) of tert-butyl 4-ethoxycarbonylpiperidine-1-carboxylate is dissolved in 4 mL of THF at −10° C. 0.8 mL (1.56 mmol) of lithium diisopropylamide is added dropwise. After 15 minutes, 0.09 mL (1.2 mmol) of iodoethane is added and the mixture is warmed to room temperature. It is stirred for 30 minutes and then poured into saturated ammonium chloride solution and extracted with ethyl acetate. The organic phase is dried and then concentrated to dryness. The oil obtained is chromatographed on silica gel (eluent: 95/5 heptane/ethyl acetate). 183 mg of tert-butyl 4-ethyl-4-ethoxycarbonylpiperidine-1-carboxylate in the form of a yellow oil are obtained in a yield of 82%.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic phase is dried
  3. concentrationconcentrated to dryness
  4. customThe oil obtained
  5. customis chromatographed on silica gel (eluent: 95/5 heptane/ethyl acetate)

출처 및 근거

ORD 기록
ord-c0d67e2194f64c37a95bbd3bcda12e8d
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877968B2

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