Methyl iodide → 6-Nitro-o-anisidine

HRID 33386

반응식

HRID 33386 반응식
[OH-].[K+].[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:13].I[CH3:15]>CN(C=O)C>[CH3:15][O:13][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([N+:10]([O-:12])=[O:11])[C:4]=1[NH2:3]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 41154952-Amino-3-Nitrophenol

생성물 1

HCID 854916-Nitro-o-anisidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

85% potassium hydroxide solution (11.7 g, 0.179 mol) is added to a solution of 25 g (0.162 mol) 2-amino-3-nitro-phenol in 200 mL DMF. Then 11.1 mL (0.178 mol) iodomethane are added dropwise and the mixture is stirred overnight at ambient temperature. The reaction mixture is poured onto ice and stirred for one hour. The precipitated product is filtered off, washed with water and dried.

후처리

  1. additionThe reaction mixture is poured onto ice
  2. stirringstirred for one hour
  3. filtrationThe precipitated product is filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-256aa94f9e5847479f45c40f7a09c03e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429583B2

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