1-Methoxy-2-propanol → HCID 17750604, 화합물

HRID 333930

반응식

HRID 333930 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[CH:3]=1.COCC(O)C.[N:19]1([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:12][C:4]1[CH:3]=[C:2]([N:22]2[CH2:21][CH2:20][N:19]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:24][CH2:23]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

참가 물질

4

반응물 3

HCID 79001-Methoxy-2-propanolHCID 779734-Chloro-2-methylquinolineHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 17750604HCID 17750604, 화합물

실험 절차

4-Chloro-2-methylquinoline (5 g, 28 mmol) was mixed with 1-methoxy-2-propanol, tert-butyl piperazine-1-carboxylate was added (5.74 g, 30.8 mmol) and the mixture was refluxed for 4.5 hours after which the product started to precipitate. The mixture was concentrated under reduced pressure and left at room temperature for 48 hours. The product was separated by filtration, washed with ethylacetate and dried at 50° C. 4.382 g of a solid were obtained (13.38 mmol, 48%). MS (APCI): m/z=327.9 [M+1]+.

후처리

  1. additionwas added (5.74 g, 30.8 mmol)
  2. temperaturethe mixture was refluxed for 4.5 hours after which the product
  3. customto precipitate
  4. concentrationThe mixture was concentrated under reduced pressure
  5. customThe product was separated by filtration
  6. washwashed with ethylacetate
  7. customdried at 50° C

출처 및 근거

ORD 기록
ord-183f7a13eb6341c1a117023f1fbe0cec
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883791B2

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