Hydrochloric Acid → 4-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-5-yl]quinoline hydrochloride

HRID 333942노트

반응식

HRID 333942 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([N:11]2[CH2:16][C@@H:15]3[CH2:17][C@H:12]2[CH2:13][N:14]3C(OC(C)(C)C)=O)=[CH:3][CH:2]=1.[ClH:25]>O1CCOCC1>[ClH:25].[C@H:15]12[CH2:17][C@H:12]([N:11]([C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=[CH:2][CH:3]=3)[CH2:16]1)[CH2:13][NH:14]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86691594tert-Butyl (1S,4S)-5-(4-quinolyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

생성물 1

HCID 668355714-[(1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-5-yl]quinoline hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

tert-Butyl (1S,4S)-5-(4-quinolyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (325 mg from step A) was dissolved in a 4M solution of HCl in anhydrous dioxane (4 ml) and stirred for one hour at room temperature. The volatiles were evaporated under reduced pressure, the residue was triturated two times with diethylether and the supernatant removed. The residue was dried in vacuo to obtain 317 mg of a solid. MS (APCI) m/z=225.9 [M+H]+.

후처리

  1. customThe volatiles were evaporated under reduced pressure
  2. customthe residue was triturated two times with diethylether
  3. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-60e96f84bf0f4e4aa2c21824645165de
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883791B2

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