Sodium Hydroxide → (E)-4,4,5,5-tetrafluoropent-2-enoic acid

HRID 333977노트

반응식

HRID 333977 반응식
[F:1][C:2]([F:13])([CH:10]([F:12])[F:11])/[CH:3]=[CH:4]/[C:5]([O:7]CC)=[O:6].[OH-].[Na+]>C(O)C.O>[F:1][C:2]([F:13])([CH:10]([F:11])[F:12])/[CH:3]=[CH:4]/[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 86691166Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate

생성물 1

HCID 86691165(E)-4,4,5,5-tetrafluoropent-2-enoic acid수율 93%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate (15.9 g, 0.08 mol) was dissolved in ethanol (30 ml), 4M NaOH was added (15 ml) and the mixture was stirred at room temperature overnight. The mixture was diluted with water, washed with ethylacetate, acidified with 1M HCl and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, the solvent was removed under reduced pressure. 12.8 g of a colourless oil were obtained (0.074 mmol, 93%). MS (ESI) m/z=170.9 [M−1]−.

후처리

  1. washwashed with ethylacetate
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. dry with materialwas dried over magnesium sulfate
  5. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-38df27479b75412a8427a10870eababf
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883791B2

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