Sodium Hydroxide → 1-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

HRID 334009노트

반응식

HRID 334009 반응식
C[O:2][C:3]([C:5]1[N:9]=[CH:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[N:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.O>[Cl:16][C:12]1[CH:11]=[C:10]([N:7]2[CH:8]=[N:9][C:5]([C:3]([OH:4])=[O:2])=[N:6]2)[CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 694601791-(3-chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester

생성물 1

HCID 713019271-(3-Chlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

실험 절차

14.8 g (62.3 mmol) 1-(3-chloro-phenyl)-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester was taken up in 70 mL THF and treated with 40 mL 4M aqueous NaOH solution at RT for 12 h. The reaction mixture was diluted with water, THF was removed by distillation, ice water was added and the mixture was acidified with 4 M aqueous HCl solution. The precipitated was filtered off, washed with water and triturated with diethyl ether.

후처리

  1. customwas removed by distillation, ice water
  2. additionwas added
  3. filtrationThe precipitated was filtered off
  4. washwashed with water
  5. customtriturated with diethyl ether

출처 및 근거

ORD 기록
ord-e4d67e829e2d4b528419bf968f0a800a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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