Diisopropylethylamine → 4-(6-Cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester

HRID 334017노트

반응식

HRID 334017 반응식
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([OH:12])=O)[CH:7]=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C.FC(F)(F)C(O)=O.[CH2:51]([O:58][C:59]([N:61]1[CH2:66][CH2:65][NH:64][CH2:63][C:62]1([CH3:68])[CH3:67])=[O:60])[C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1>CN(C=O)C.O>[CH2:51]([O:58][C:59]([N:61]1[CH2:66][CH2:65][N:64]([C:10]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([CH:1]3[CH2:2][CH2:3]3)[N:9]=2)=[O:12])[CH2:63][C:62]1([CH3:68])[CH3:67])=[O:60])[C:52]1[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=1

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 824151916-Cyclopropylpicolinic acidHCID 866882432,2-Dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate

생성물 1

HCID 866882444-(6-Cyclopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

200 mg (1.23 mmol) 6-cyclopropyl-pyridine-2-carboxylic acid was stirred with 450 mg (1.40 mmol) TBTU and 500 μL (2.91 mmol) DIPEA in 5.0 mL DMF at RT. After 10 min, 440 mg (1.23 mmol) 2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate was added and the reaction mixture was stirred at RT over night. Water was added and the product was extracted with EtOAc. The organic layers were dried over sodium sulfate and concentrated in vacuo.

후처리

  1. extractionthe product was extracted with EtOAc
  2. dry with materialThe organic layers were dried over sodium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-92ce12ddab974b9ebbd9bffa03e183d8
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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