Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334054

반응식

HRID 334054 반응식
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

생성물 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

반응 조건

온도
150 °C

실험 절차

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

후처리

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-d4a7b52437e44155b9cd4be82e8585e1
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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