Sodium Hydroxide → 4-Bromo-6-methoxy-2-pyridinecarboxylic acid

HRID 334058노트

반응식

HRID 334058 반응식
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([O:12][CH3:13])[N:6]=1)=[O:4].[OH-].[Na+]>CO>[Br:11][C:9]1[CH:8]=[C:7]([O:12][CH3:13])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86688282Methyl 4-bromo-6-methoxypicolinate

생성물 1

HCID 155103794-Bromo-6-methoxy-2-pyridinecarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

246 mg (1.00 mmol) 4-bromo-6-methoxy-pyridine-2-carboxylic acid methyl ester was dissolved in 5 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation. the residue was taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.

후처리

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-cb2239ce1f4c4526bc894a4439b55e38
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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