Sodium Hydroxide → HCID 84696473, 화합물

HRID 334059노트

반응식

HRID 334059 반응식
C[O:2][C:3]([C:5]1[N:6]=[C:7]([O:17][CH3:18])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH3:18][O:17][C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866882833-Isoquinolinecarboxylic acid, 1,6-dimethoxy-, methyl ester

생성물 1

HCID 84696473HCID 84696473, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

500 mg (2.02 mmol) 1,6-dimethoxy-isoquinoline-3-carboxylic acid methyl ester was dissolved in 20 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and purified by HPLC.

후처리

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. custompurified by HPLC

출처 및 근거

ORD 기록
ord-9c1a3869d16e4b3b965d2666b7d5a2aa
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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