Methanol → 3-Chloro-6-fluoro-1-methoxyisoquinoline
반응식
[Na].Cl[C:3]1[C:12]2[C:7](=[CH:8][C:9]([F:13])=[CH:10][CH:11]=2)[CH:6]=[C:5]([Cl:14])[N:4]=1.[CH3:15][OH:16]>>[Cl:14][C:5]1[N:4]=[C:3]([O:16][CH3:15])[C:12]2[C:7]([CH:6]=1)=[CH:8][C:9]([F:13])=[CH:10][CH:11]=2참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 125 mg (3.00 mmol) sodium in 40 mL MeOH was added 668 mg (3.00 mmol) 1,3-dichloro-6-fluoro-isoquinoline. The reaction mixture was stirred at 70° C. for 30 min. The solvent was removed by distillation and the residue diluted with ice water. The precipitate was filtered off, washed with water and dried.
후처리
- customThe solvent was removed by distillation
- additionthe residue diluted with ice water
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-c8d994cb1d8a44069c3b782386cadbb7
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883789B2
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