Methoxyacetone → HCID 86688304, 화합물

HRID 334081

반응식

HRID 334081 반응식
[CH3:1][O:2][CH2:3][C:4](=O)[CH3:5].[CH2:7]([O:9][C:10](=[O:20])[CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:8].C[Si]([C:25]#[N:26])(C)C>C(O)(=O)C>[CH2:7]([O:9][C:10](=[O:20])[CH2:11][N:12]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:4]([C:25]#[N:26])([CH3:5])[CH2:3][O:2][CH3:1])[CH3:8]

참가 물질

5

반응물 3

HCID 22172MethoxyacetoneHCID 80908N-Benzylglycine ethyl esterHCID 82115Trimethylsilyl cyanide

생성물 1

HCID 86688304HCID 86688304, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

To a mixture of 500 μL (5.43 mmol) methoxyacetone and 1.05 g (5.43 mmol) N-benzylglycine ethyl ester in 2.0 mL acetic acid was added 780 μl (6.18 mmol) trimethylsilyl cyanide dropwise. The resulting mixture was stirred at 80° C. for 30 min and then poured into ice water. The water was decanted and the oily residue was triturated with DIPE. The precipitate was filtered off and the solvent was washed with saturated aqueous NaHCO3 solution, dried over sodium sulfate, filtered and concentrated in vacuo.

후처리

  1. customThe water was decanted
  2. customthe oily residue was triturated with DIPE
  3. filtrationThe precipitate was filtered off
  4. washthe solvent was washed with saturated aqueous NaHCO3 solution
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8ec03467cdcf4320a65d9f7ac1eee16f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883789B2

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