Isopropanol → HCID 178494015, 화합물

HRID 334393노트

반응식

[OH2:1].[NH2:2][NH2:3].[I:4][C:5]1[C:6](OC)=[N:7][C:8](S(C)=O)=[C:9]([CH:12]=1)[C:10]#[N:11].[CH3:18]C(O)C>>[I:4][C:5]1[CH:12]=[C:9]2[C:10]([NH2:11])=[N:3][NH:2][C:8]2=[N:7][C:6]=1[O:1][CH3:18]

참가 물질

반응물 3

HCID 3776Isopropanol

HCID 24654Hydrazine hydrate (1:1)

HCID 68276344HCID 68276344, 화합물

생성물 1

HCID 178494015HCID 178494015, 화합물수율 78%

반응 조건

온도: 80 °C

실험 절차

294 μl (1.2 eq) of hydrazine monohydrate is added to a solution of 1.63 g (5.05 mmol) of 5-iodo-6-methoxy-2-(methylsulfinyl)nicotinonitrile in 30 ml of 2-propanol. The reaction medium is stirred at 80° C. for 9 hours. After returning to room temperature, the solid formed is filtered and rinsed with 2-propanol to yield 1.14 g (78%) of 5-iodo-6-methoxy-1H-pyrazolo[3,4-b]pyridin-3-amine in the form of a white powder.

후처리

customAfter returning to room temperature
customthe solid formed
filtrationis filtered
washrinsed with 2-propanol

출처 및 근거

ORD 기록: ord-671dfdc821404ef18c0d4e9744323f73
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08883821B2

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