5-Nitrofuroyl chloride → 5-nitro-N-[2-(piperidin-1-yl)phenyl]furan-2-carboxamide

반응식

[N+:1]([C:4]1[O:8][C:7]([C:9](Cl)=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[N:12]1([C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH2:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:9]([C:7]2[O:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)=[O:10])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 907115-Nitrofuroyl chloride

HCID 4587952-(Piperidin-1-yl)aniline

생성물 1

HCID 29956205-nitro-N-[2-(piperidin-1-yl)phenyl]furan-2-carboxamide수율 100%

실험 절차

The compound was prepared according to the procedure described in Example 2 from 5-nitro-furan-2-carbonyl chloride and 2-piperidinoaniline. Yield: 100%. MS: 316 (M+1). LC/MS purity: 100%. 1HNMR (CDCl3, 300 MHz): δ 8.2 (d, 1H), 7.85 (d, 1H), 7.55 (m, 1H), 7.4 (m, 3H), 3.8-3.2 (bm, 4H), 2.7-1.9 (bm, 6H).

후처리

customThe compound was prepared

출처 및 근거

ORD 기록: ord-a048a0ae055d459d856eeafc414d3f81
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07429603B2

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