Chloroacetic Acid → 1-Benzyl-2-chloromethyl-1H-benzoimidazole

HRID 334740노트

반응식

HRID 334740 반응식
[CH2:1]([NH:8][C:9]1[C:10]([NH2:15])=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:16][CH2:17][C:18](O)=O>>[CH2:1]([N:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]=[C:18]1[CH2:17][Cl:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 300Chloroacetic AcidHCID 2735482N1-Benzylbenzene-1,2-diamine

생성물 1

HCID 5634361-Benzyl-2-chloromethyl-1H-benzoimidazole수율 61.7%

실험 절차

The title compound was prepared in accordance with the general method of Example 191(C), from N1-benzylbenzene-1,2-diamine (2.93 g, 14.78 mmol) and 2-chloroacetic acid (2.10 g, 22 mmol). The crude residue was purified over silicagel chromatography (prepacked 70 g silicagel column, Cyclohexane/AcOEt: from 80/20 to 70/30 as eluent) to afford 2.34 g of 1-benzyl-2-(chloromethyl)-1H-benzo[d]imidazole (Yield: 61%) as a yellow oil.

후처리

  1. customThe crude residue was purified over silicagel chromatography (prepacked 70 g silicagel column, Cyclohexane/AcOEt: from 80/20 to 70/30 as eluent)

출처 및 근거

ORD 기록
ord-9ee45461a2524e05be783d96d82557ee
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883826B2

반응 노트

불러오는 중…